Remember New coronavirus resource library was released
On January 22, 2020, the National Genomics Science Data
Center officially released the 2019 new coronavirus resource library. The
library integrates corona virus genome sequence data and meta information
published by the World Health Organization (WHO), the Chinese Center for
Disease Control and Prevention (CDC), the National Center for Biotechnology
Information (NCBI), and the Global Influenza Sequence Database (GISAID). ,
Academic literature, news, popular science articles. At the same time, mutation
analysis and display of the genome sequence of different coronavirus strains.
The 2019 New Coronavirus Resource Library contains meta
information of the 2019 New Coronavirus (2019-nCoV) virus strains from the NCBI
GenBank database and GISAID database, including the strain name, sampling date,
sampling location, sample providing unit, data submission unit, etc.
Through this resource library, you can also access the
Coronaviridae genome and protein sequences collected from the public database
of the National Genome Science Data Center Genome Database GWH.
Users can base on Accession Data
Users can base
on Accession number, species name, genus name, sampling date, sampling
location, host, separation Source, release date and other meta-information
screen the corona virus strains of interest, and personalize the selected
sequence to download to carry out relevant scientific research.
The 2019 new coronavirus resource library will continue to
update meta information and genomic sequence data, and monitor the academic
documents of 2019 new coronavirus and other coronaviruses published in NCBI's
PubMed database in real time, and the news released by China News and Xinhuanet
to update the world simultaneously The popular science introduction issued by
WHO and the Chinese Center for Disease Control and Prevention provides
resources and windows for users to carry out academic research, master
scientific research progress, understand news and scientific knowledge.
The 2019 new coronavirus resource library carried out
2019-nCoV virus strain genome variation analysis based on different reference
genome sequences, and statistically and visually displayed the results. Through
the comparison of genome-wide sequence similarity and analysis of mutation
sites, the degree of variation, variation region, and variation between
2019-nCoV virus strains, 2019-nCoV virus strains and SARS coronavirus, and
SARS-like coronavirus bat strains are obtained Base details.
According to data
analysis, the 2019-nCoV genome sequence sequence similarity to the SARS virus
outbreak in 2003 was 80%, which was similar to the Bat SARS-like coronavirus
isolate bat-SL-CoVZC45 genome sequence sequence collected from domestic bats in
February 2017 The highest, the similarity is 88%.
Genomic variation analysis of
the 2019-nCoV virus strain can provide an important data foundation and
decision support for tracing the source of the virus, tracking the mutation
path of the virus strain, preventing and controlling the epidemic caused by the
new coronavirus, and treating viral pneumonia.
2019 New Coronavirus Genome Variation Analysis
The reference
genome for genomic variation analysis is GenBank 2019 new coronavirus strain
genome sequence MN908947.3, SARS-Cov is SARS coronavirus, bat-SL-CoVZC45 is
SARS-like coronavirus bat strain, The rest of the genome sequence is derived
from the 2019 new coronavirus strain released by GISAID. The red vertical line
indicates the mutation site.
0 Comments
Thanks for your comment!