Corona virus Latest Update in China. Chinese Corona Virus Updates
Few Days ago, when Chinese General Secretary Xi Jinping chaired the
meeting of the Standing Committee of the Political Bureau of the CPC Central
Committee, he pointed out that it is necessary to insist on accelerating the
full restoration of production and living order in the prevention and control
of normalized epidemic situations. The meeting also emphasized that party
committees and governments at all levels should enhance their sense of urgency,
optimize measures for prevention and control of epidemic conditions according
to local conditions and time, do everything possible to create conditions
conducive to resumption of production and production, and take the opportunity
to unblock industrial, market and economic and social cycles.
The Standing Committee of the Political Bureau of the CPC
Central
Since the epidemic occurred, Xi Jinping has always adhered to
a "national chess game", deployed the prevention and control of the
epidemic according to the situation and the situation, and coordinated the
promotion of economic and social development. The implementation of normalized
epidemic prevention and control is a scientific deployment made by General
Secretary Xi Jinping based on the current situation of epidemic prevention and
control at home and abroad. The opportunity to unblock the "three
cycles" is the key to good prevention and control and the development of
"a game of chess."
Pain doesn't work, but it doesn't hurt. Economic society is a
dynamic circulation system, and smooth circulation is the prerequisite for the
healthy operation of economic society. How to smooth the circulation, Xi
Jinping always pay attention to the "epidemic" throughout the war.
CCTV's "Hot Interpretation" will analyze it for you.
Smooth the industrial cycle, focusing on "upstream and
downstream production and marketing docking" and "blocking
points". Industrial chains are interlocked, and one link is blocked, and
upstream and downstream enterprises cannot operate. Since the outbreak, the
domestic and global industrial chains have been hit.
Xi Jinping urged: "We must strengthen the connection
between upstream and downstream production and sales between regions, and
promote the coordinated resumption of production in all links of the industrial
chain." The overseas epidemic impacted China's foreign trade industrial
chain, supply chain and Xi Jinping Reminder:
"We must strengthen the
research and analysis of the international economic situation and formulate
targeted policies and measures in a timely manner."
Some traditional
industries have been hit hard, while emerging industries such as smart
manufacturing, unmanned distribution, and online consumption have shown strong
growth potential. Xi Jinping encouraged:
"Take this as an opportunity to
transform and upgrade traditional industries and cultivate and grow new
industries." As Xi Jinping said, "This is a crisis, but also a big
test", "Dangerous opportunities always coexist with each other and
have been overcome. Danger is opportunity. "
Smooth the market cycle, focusing on the "double
upgrade" of industrial consumption and then the "breakpoint".
Production and consumption are the two basic elements of the market cycle.
Consumption is the ultimate goal and power of production, and it is the
"main engine" that drives China's economic growth. Today, with
economic growth led by consumption, the "dual upgrade" of industrial
consumption is a key measure to further smooth the market cycle.
At the meeting
of the Standing Committee of the Political Bureau of the CPC Central Committee
held on February 3, Xi Jinping prescribed the development of prescriptions:
"Expanding consumption is one of the important points of impact on the
impact of the epidemic."
Now that the epidemic prevention and control
situation is steadily improving, we must follow the general secretary requirements, combining the resumption of production and the expansion of
domestic demand, releasing the suppressed and frozen consumption, and making
great articles on consumption.
Smooth the economic and social circulation, focusing on
"people complaining to the people and asking the people's wishes" to
break "difficult points". The economic and social cycle is a higher
level and more comprehensive dynamic cycle. It is not only the need for
enterprises to resume production and production, but also the people's
livelihood. During the "epidemic" war, from allowing college
graduates to graduate smoothly and get employed as soon as possible, to caring
for the lonely elderly, difficult children, and severely ill and disabled
people who were isolated at home because of the epidemic.
From enriching the
residents' "vegetable baskets" and carrying out "rice bags"
to strengthening the psychological counseling and intervention of the masses,
the general secretary has the attention of the places where the people are
concerned.
Adhering to the people as the center, guided by the good
expectations of the people, taking the "difficulties" of people's
livelihood as the focus of the smooth economic and social cycle, focusing on
the overall attack, promoting the speed of resumption of production, and
promoting the "six stability" to achieve energy Continued virtuous
circle of economic society.
China's economy is a sea
"Rapid wind and rain can
overturn a small pond, but not the sea." The anti-epidemic is still going
on, and the resumption of production and production is also advancing.
According to the deployment of the Politburo Standing Committee meeting of the
Communist Party of China, while implementing the normalization of epidemic
prevention and control, at the same time, the industry cycle, the market cycle,
and the economic and social cycle will be unblocked. "Being stable and
far-reaching, we will welcome the spread of the epidemic."
New Coronavirus Pneumonia Warning Information
Update
Few Days ago, when Chinese General Secretary Xi Jinping chaired the
meeting of the Standing Committee of the Political Bureau of the CPC Central
Committee, he pointed out that it is necessary to insist on accelerating the
full restoration of production and living order in the prevention and control
of normalized epidemic situations. The meeting also emphasized that party
committees and governments at all levels should enhance their sense of urgency,
optimize measures for prevention and control of epidemic conditions according
to local conditions and time, do everything possible to create conditions
conducive to resumption of production and production, and take the opportunity
to unblock industrial, market and economic and social cycles.
The Standing Committee of the Political Bureau of the CPC Central
Since the epidemic occurred, Xi Jinping has always adhered to
a "national chess game", deployed the prevention and control of the
epidemic according to the situation and the situation, and coordinated the
promotion of economic and social development. The implementation of normalized
epidemic prevention and control is a scientific deployment made by General
Secretary Xi Jinping based on the current situation of epidemic prevention and
control at home and abroad. The opportunity to unblock the "three
cycles" is the key to good prevention and control and the development of
"a game of chess."
Pain doesn't work, but it doesn't hurt. Economic society is a
dynamic circulation system, and smooth circulation is the prerequisite for the
healthy operation of economic society. How to smooth the circulation, Xi
Jinping always pay attention to the "epidemic" throughout the war.
CCTV's "Hot Interpretation" will analyze it for you.
Smooth the industrial cycle, focusing on "upstream and
downstream production and marketing docking" and "blocking
points". Industrial chains are interlocked, and one link is blocked, and
upstream and downstream enterprises cannot operate. Since the outbreak, the
domestic and global industrial chains have been hit.
Xi Jinping urged: "We must strengthen the connection
between upstream and downstream production and sales between regions, and
promote the coordinated resumption of production in all links of the industrial
chain." The overseas epidemic impacted China's foreign trade industrial
chain, supply chain and Xi Jinping Reminder:
"We must strengthen the
research and analysis of the international economic situation and formulate
targeted policies and measures in a timely manner."
Some traditional
industries have been hit hard, while emerging industries such as smart
manufacturing, unmanned distribution, and online consumption have shown strong
growth potential. Xi Jinping encouraged:
"Take this as an opportunity to
transform and upgrade traditional industries and cultivate and grow new
industries." As Xi Jinping said, "This is a crisis, but also a big
test", "Dangerous opportunities always coexist with each other and
have been overcome. Danger is opportunity. "
Smooth the market cycle, focusing on the "double
upgrade" of industrial consumption and then the "breakpoint".
Production and consumption are the two basic elements of the market cycle.
Consumption is the ultimate goal and power of production, and it is the
"main engine" that drives China's economic growth. Today, with
economic growth led by consumption, the "dual upgrade" of industrial
consumption is a key measure to further smooth the market cycle.
At the meeting
of the Standing Committee of the Political Bureau of the CPC Central Committee
held on February 3, Xi Jinping prescribed the development of prescriptions:
"Expanding consumption is one of the important points of impact on the
impact of the epidemic."
Now that the epidemic prevention and control
situation is steadily improving, we must follow the general secretary requirements, combining the resumption of production and the expansion of
domestic demand, releasing the suppressed and frozen consumption, and making
great articles on consumption.
Smooth the economic and social circulation, focusing on
"people complaining to the people and asking the people's wishes" to
break "difficult points". The economic and social cycle is a higher
level and more comprehensive dynamic cycle. It is not only the need for
enterprises to resume production and production, but also the people's
livelihood. During the "epidemic" war, from allowing college
graduates to graduate smoothly and get employed as soon as possible, to caring
for the lonely elderly, difficult children, and severely ill and disabled
people who were isolated at home because of the epidemic.
From enriching the
residents' "vegetable baskets" and carrying out "rice bags"
to strengthening the psychological counseling and intervention of the masses,
the general secretary has the attention of the places where the people are
concerned.
Adhering to the people as the center, guided by the good
expectations of the people, taking the "difficulties" of people's
livelihood as the focus of the smooth economic and social cycle, focusing on
the overall attack, promoting the speed of resumption of production, and
promoting the "six stability" to achieve energy Continued virtuous
circle of economic society.
China's economy is a sea
"Rapid wind and rain can
overturn a small pond, but not the sea." The anti-epidemic is still going
on, and the resumption of production and production is also advancing.
According to the deployment of the Politburo Standing Committee meeting of the
Communist Party of China, while implementing the normalization of epidemic
prevention and control, at the same time, the industry cycle, the market cycle,
and the economic and social cycle will be unblocked. "Being stable and
far-reaching, we will welcome the spread of the epidemic."
New Coronavirus Pneumonia Warning Information Update
Activating dormant consumer: A meeting of the Standing Committee of the Political Bureau
of the Central Committee recently proposed that efforts should be made to
expand domestic demand, and make arrangements for orderly promotion of
resumption of work and resumption of the market, and active expansion of
residents' consumption. Under the circumstances that the international epidemic
continues to spread, the downside risks of the world economy are intensified,
and external demand is significantly inhibited, boosting the confidence of the
domestic consumer market and activating the dormant consumption potential are
of even greater importance and urgency to promote the healthy development of
the economy and society.
The epidemic has a great impact on China's consumer sector.
However, we must also see that as one of the world’s largest consumer markets, China’s
market demand has grown rapidly, has sustained growth, and has a strong driving
force. The momentum of strong production capacity supported by a complete
industrial chain and a booming service industry has not changed.
The foundation
remains solid. The urgent task of expanding consumption is to increase the implementation
of the policy of resuming production and production, orderly promote the
resumption of work in various shopping malls and markets, promote the normal
operation of the life service industry, release the suppressed and frozen
consumption, and prevent and control the epidemic.
The new type of consumption
and upgraded consumption that have been catalyzed by China have been nurtured
and strengthened to make up for consumption in kind and services, and strive to
minimize the losses caused by the epidemic.
To actively expand consumption, we must accelerate the
release of emerging consumption potential. During the epidemic, some industry
companies, especially new business models, new models and new products, grew
against the trend, and online services such as express delivery, fresh
e-commerce, online education, remote consultation, and remote office services
expanded rapidly. China must seize the new opportunities for the rapid
development of the digital economy, accelerate the construction of new infrastructure,
actively enrich 5G technology application scenarios, drive the consumption of
5G mobile phones and other terminals, and promote the "dual upgrade"
of industry and consumption.
To actively expand consumption, China must comprehensively
promote healthy consumption. Taking the epidemic prevention and control as an
opportunity, we will further promote a healthy lifestyle, guide enterprises to
increase the supply of related products and services, expand the production and
sales of green food, medicines, hygiene products, and fitness equipment, so as
to better meet residents' healthy lifestyle consumption needs.
To actively expand consumption, we must expand the
consumption of quality-enhancing services and stabilize traditional
consumption. Housekeeping services, old-age care, and other service consumers
are in urgent need and have a large employment capacity. It is necessary to
strengthen policy guidance and fully mobilize the enthusiasm of social forces
to participate.
To actively stabilize traditional bulk consumption such as
automobiles, and encourage automobile purchase areas to appropriately increase
automobile license plate quotas. Drive the consumption of automobiles and
related products, so as to fully release the market advantage and domestic demand
potential of ultra-large scale.
It is worth noting that consumer power directly affects
consumer expectations and consumer confidence
The current difficulties faced
by China's economic development are increasing. It is necessary to strengthen
the support for difficult industries and small, medium and micro enterprises,
comprehensively strengthen the employment stabilization measures, and
effectively ensure the protection of the groups of people with employment
difficulties. It is necessary to strengthen the supervision of market order,
actively promote the construction of a credit system in the consumer field,
unblock channels for consumer rights protection, comprehensively create a safe
and safe consumer environment, and allow consumers to eat their minds and
enhance their sense of gain.
Consumption is the ultimate demand and the lasting driving
force of economic growth. Since the outbreak of the epidemic, 23 departments
have jointly launched 19 hard measures to promote consumption. Several cities across
the country issued consumer vouchers and relaxed restrictions on car purchases.
A series of consumption promotion policies have been introduced intensively and
are showing positive results. Starting from meeting the people's growing needs
for a better life, we must deepen reforms to continuously break down the
institutional barriers that restrict consumption, and promote the organic
integration of supply and demand, consumption replenishment, and expansion of
increments, which will surely inject lasting power into economic growth.
April 10, Zhumadian City Health and Sports Commission issued a new coronavirus pneumonia reminder
[Warning update] [Zhumadian City Health and Sports Commission
issued a new coronavirus pneumonia reminder]: World Health Day China theme is
"Salute for medical care and fight against the epidemic". In this
battle without smoke, the majority of white soldiers traveled retrogressively,
excluding life and death. They interpreted their original mission with
practical actions and wrote a touching chapter in the new era. Here we pay our
highest tribute to the vast number of medical staff who bravely fight against
the outbreak of new pneumonia!
(Source: Chinese National Early Warning Release Center)
Tsinghua and Shenzhen Third Hospital isolate neocrown virus
antibodies, will promote clinical application
At present, Zhang Linqi and Zhang Zheng's team are
collaborating with Professor Wang Xinquan of the School of Life Sciences,
Tsinghua University to conduct systematic structural and functional research on
these antibodies, select the optimal antibodies, and promote large-scale production,
preclinical animal research and subsequent clinical application development.
Beijing News (Reporter Fan Shuo) Recently, Zhang Linqi's team
at the Tsinghua University School of Medicine and Zhang Zheng's research team
at the Shenzhen Third People's Hospital successfully isolated more than 200
anti-neoviruses from blood B lymphocytes in patients with neo-coronary
pneumonia. Monoclonal antibodies and their encoding genes. The results have
been published on the preprinted platform BioRxiv. In an interview with the
Beijing News on March 29, the above team stated that they are currently
collaborating with Professor Wang Xinquan of the School of Life Sciences at
Tsinghua University to select the best antibodies to promote large-scale
production, preclinical animal research and follow-up clinical applications,
Development.
Monoclonal antibodies or new crown specific drugs
Zhang Linqi told reporters that this monoclonal antibody
only has a strong recognition effect on the new crown virus, "this
antibody belongs to the specific drug against the new crown virus."
The paper published by Zhang Linqi and Zhang Zheng's research
team on BioRxiv showed that the invasion of human cedar virus by humans depends
on the binding between the virus S protein receptor binding domain (RBD) and
the target of the cell angiotensin converting enzyme 2 (ACE2) receptor.
The
above-mentioned team isolated 206 monoclonal antibodies against neocoronavirus,
two of which showed strong anti-neurovirus, which can convert neocoronavirus S
protein receptor binding domain (RBD) and angiotensin in human cells. Enzyme 2
(ACE2) binding decreased by 99.2% and 98.5%.
On February 8th, the National Health and Medical Commission's
"Diagnosis and Treatment of New Coronavirus Pneumonia" (the fifth
revised version of the trial) mentioned that the treatment plan for severe and
critical cases can be treated with recovery plasma. Among them, antibodies
present in the plasma during recovery of patients with new coronary pneumonia
are the key to help the treatment of critically ill patients.
According to Zhang Zheng, there are two main methods of
plasma treatment at present, one is to directly use the recovery period plasma,
and the other is to extract the immunoglobulin from the recovery period plasma.
Although it has been clinically proven to have a certain effect on new coronary
pneumonia, in the traditional "plasma therapy", there are problems
such as trans blood type, low efficiency, difficult to save plasma, and limited
sources. The immunoglobulin extracted from the plasma during recovery is
actually a polyclonal antibody, and there is also a problem of low efficiency
in clinical treatment.
"The antibodies in the recovery plasma are actually a
mixture of tens of thousands of antibodies." Zhang Linqi said that the
team's method of extracting monoclonal antibodies was actually selecting high
efficiency from tens of millions of different antibody mixtures. A key antibody
that blocks the virus from entering the cell, breaking the virus's replication
chain.
A lot of work is still needed for clinical application
A lot of work is still needed from the currently isolated
antibodies to the actual application to patients. At present, Zhang Linqi and
Zhang Zheng's team are collaborating with Professor Wang Xinquan of the School
of Life Sciences, Tsinghua University to conduct systematic structural and
functional research on these antibodies, select the optimal antibodies, and
promote large-scale production, preclinical animal research, and subsequent
clinical application development.
"The whole process is as short as possible." Zhang
Linqi revealed that it usually takes 9 months to a year and a half from the
routine antibody development to the clinical trial. "The country has
actually established a good service platform, and we also I am confident that I
will be able to complete a large number of production and process development
and animal safety assessments in about six months, and then report to the drug
review center for a Phase I clinical trial. "
New study: pangolin carries coronavirus similar to new coronavirus
Researchers from Shantou University-Hong Kong University Joint Institute of
Virology and Guangxi Medical University have reported in the British journal
Nature that they have smuggled pangolin samples Coronaviruses similar to
neocoronaviruses were found.
However, this similarity is not enough to indicate
that pangolin is the intermediate host that caused the current outbreak.
Researchers obtained multiple smuggled pangolin samples
intercepted in Guangxi, Guangdong, China in recent years, and analyzed the
samples by high-throughput RNA (ribonucleic acid) analysis. They found that the
pangolins carry coronaviruses that are similar to the new coronavirus genome
sequences Degrees range from 85.5% to 92.4%.
The analysis shows that on the coronavirus evolution tree,
the coronaviruses and neocoronaviruses carried by these pangolins are in the
"new coronavirus-related evolutionary branch". The pangolins that
carry coronavirus belong to two subtypes of this branch, one of which The
Knappin receptor binding domain is 97.4% similar to Neocoronavirus.
The receptor-binding domain of spike protein acts like a
"hook" that can hook into the host cell and plays a key role in the
process of virus invasion.
To date, the closest known strain to the new coronavirus is
the coronavirus found by bats from researchers such as the Wuhan Institute of
Virology of the Chinese Academy of Sciences. It has 96% identity with the new
coronavirus genome and a similarity in the receptor binding domain of 89.2%.
Researchers said pangolins are the only mammals known to have
been infected with a coronavirus associated with a coronavirus to date, except
bats, and may be a long-term host for such viruses.
Researchers point out that the latest findings are not enough
to indicate that pangolin is the intermediate host that caused the current
outbreak, but it should be considered as a possible host of the new crown
virus. Strictly banning pangolin trading in the market will reduce the risk of
future virus transmission to humans.
Previously, a team from Lingnan Modern Agricultural Science
and Technology Guangdong Laboratory and South China Agricultural University
published a preprinted paper saying that their pangolin spliced from the metagenome
carried a coronavirus sequence that was approximately 90% similar to the new
coronavirus genome sequence, indicating that pangolins Probably an intermediate
host of the new crown virus. This paper has not been peer reviewed.
China takes the lead in launching clinical trials against
respiratory syncytial virus
China takes the lead in launching clinical trials against respiratory syncytial virus
With the advent of cold winter weather, the number of cold
patients has gradually increased. The impact of the flu epidemic last year has
made many people gradually understand and value "cold" gradually, but
it needs to be clear to everyone that "cold" is not all
"Influenza", respiratory syncytial virus (RSV) is also one of the
main culprits. After most adults are infected with this virus, the clinical
symptoms are similar to those of upper respiratory tract infections caused by
general influenza, and runny nose and cough will appear.
Academician Wang Chen speaks
At the launch of the Phase II clinical trial of the new
anti-respiratory syncytial virus AK0529 in China on November 21, Prof. Wang
Chen, member of the Chinese Academy of Engineering, director of the National
Research Center for Respiratory Diseases, and director of the Respiratory
Center of China-Japan Friendship Hospital, took charge of this project.
The
national leader said that this is the first clinical study in China and the
world to observe the efficacy in adult patients with natural infection with
respiratory syncytial virus, and it is expected to fill a gap in the field of
respiratory virus treatment at home and abroad.
It is understood that as there is no effective medicine for
the treatment of respiratory syncytial virus worldwide, it has brought a huge
burden on the health care systems of countries around the world. Most children
are infected with respiratory syncytial virus within two years after birth.
In
preterm infants, young children, immunocompromised adults, and the elderly, the
symptoms of the infection are more severe. In these high-risk groups, the
"common cold" can evolve into lower respiratory infections,
pneumonia, bronchiolitis, and other serious respiratory problems, which can be
fatal in a few cases.
Respiratory syncytial virus is highly contagious. It can be
spread through droplets from coughing or sneezing, and because it can survive
on the surface of objects, people are easily infected when they come into
contact with these contaminated things.
Outbreaks occur only in spring and
autumn and winter in temperate regions, and are endemic throughout the year in
tropical, subtropical, and cold regions. In adults, especially those with low
immunity, and the elderly, RSV infection usually causes symptoms such as nasal
congestion, runny nose, cough, fever, sore throat, and headache.
In severe
cases, the virus spreads to the lower respiratory tract, causing pneumonia and
bronchitis, and fever, Headache, sore throat, severe cough, shortness of
breath or severe dyspnea, ventilator-assisted ventilation is needed, and skin
and lips may become blue due to hypoxia.
According to WHO data, nearly 30 million elderly patients
with respiratory syncytial virus infection worldwide each year, and at least 2
million are critically ill patients. Experts from the Chinese University of
Hong Kong School of Medicine analyzed the situation of nearly 20,000 inpatients
diagnosed with respiratory virus infection in the past 15 years and found that
respiratory syncytial virus and influenza A virus were listed as the two main
killers of children and the elderly. Respiratory syncytial virus accounts for
20% of the deaths. Respiratory syncytial virus infection can last up to about
20 days.
Many patients mistakenly believe that influenza is often untreated or
used anti-influenza virus drugs. When 7 days have passed, Not getting better
and turning to anxiety, or even blindly taking medicine, further worsened the
condition.
Professor Cao Bin, Executive Deputy Director of the
Respiratory Center of China-Japan Friendship Hospital, shared the progress of
diagnosis and treatment of respiratory syncytial virus infectious diseases at
the meeting.
He noted in the report that the results of a recent
epidemiological survey show that approximately 487,247 people in the RSV
epidemic season in the UK alone require medical treatment, 17,799
hospitalizations, and 8,482 deaths.
Patients accounted for approximately 36% of
these medical treatments, 79% of hospitalizations, and 93% of deaths. Results
from Asia are similar, with data from a South Korean study showing that all-day
mortality from respiratory syncytial virus infection in patients over 18 years
is higher than influenza (18.4% vs. 6.7%) and seasonal influenza.
Compared to
the group, the risk of death from RSV infection was significantly higher.
"China currently has more than 240 million people over the age of 60, all
of whom are at high risk for respiratory syncytial virus infection.
The burden
on families and society is huge. The results of the AK0529 phase II clinical
trial in China's adults are expected to fill the virus treatment in China and
the world.
CITIC Securities: vaccines, mRNA, and adenovirus vectors will be the antidote to the new crown virus epidemic
The domestic epidemic situation is getting better, but the
overseas epidemic situation has become more serious recently. The number of
confirmed cases in many countries has surged, which has also increased the risk
of imported epidemics in China. How to overcome COVID-19 is still the focus of
the whole society.
As Academician Zhong Nanshan said, on the one hand, it is
urgent to develop a special treatment for COVID-19. On the other hand, COVID-19
is not a lifelong immunity for infection. Developing a vaccine or a more
effective solution is the most powerful technology weapon to end the epidemic.
.
Vaccines are the root cause of COVID-19 pneumonia and have attracted much attention from investors
As of the close of March 19 local time, related companies Inovio
Pharmaceuticals, Moderna and BioNTech in the field of nucleic acid vaccines
have recorded good gains after the announcement, rising 47.84% / 52.07% /
59.75% respectively, highly sought after by investors.
Domestic COVID -19
vaccine development is synchronized with the world. At the joint defense and
joint control conference of the State Council on March 17, it was mentioned
that China is carrying out the emergency development of the COVID-19 vaccine
according to five technical routes.
Among them, the scientific research team
led by Academician Chen Wei of the Academy of Military Sciences has made the
fastest progress, and completed the registration of the Phase I clinical trial
on March 17.
The preliminary results are expected to be released in 6 months.
Combining innovative second- and third-generation vaccine technologies and
relaxation of approval policies, we judge that the development of COVID-19
vaccine is expected to accelerate.
mRNA: A promising new treatment, the vaccine has completed the first subject injection (FPI)
mRNA therapy has multiple advantages such as strong immune
activity and short R & D cycle. It presents a three-legged pattern
(Moderna, BioNTech and CureVac). Currently, both Moderna and BioNTech have been
listed on NASDAQ. At the same time, traditional pharmaceutical companies have
also laid out mRNA race tracks through cooperation.
From the perspective of
research and development progress, Moderna has made the fastest progress. The
clinical phase I trial of mRNA-1273 against COVID-19 vaccine was launched on
March 16 and is the world's first clinical trial against COVID-19 vaccine.
BioNTech is close behind, and is expected to enter clinical trials in late
April. Fosun Pharma will be responsible for commercialization in China.
Adenoviral vectors: There are precedents for commercial success.
Recombinant virus vector vaccine refers to a virus that uses
a virus as a vector to insert a foreign protective antigen gene into the viral
genome and transfect cells to obtain a recombinant virus. After immunizing the
body, the corresponding protein of interest is expressed, thereby inducing an
immune response. Carrier-like vaccine. At present, a variety of viral vectors
including pox virus, adenovirus, herpes virus (HSV), etc. have been used for
vaccine research. Among them, adenoviruses have a wide range of hosts, are
prone to produce high titer virus particles, and can accommodate large
fragments of foreign genes. , Has a good application prospect in preventive
vaccine vectors. COVID-19 based on the adenovirus platform is expected to
become a research and development hotspot at home and abroad. The Ad5-nCoV
project carried out by Academician Chen Wei of the Academy of Military Sciences
is worth looking forward to.
Risk factors
Risks of uncertain R & D progress, risk of drug price
reduction, and risk of individual stock performance falling short of
expectations.
Investment Strategy
At present, mRNA and adenoviral vector vaccines are the
shortest R & D cycle and the best commercialization technology path.
Domestic listed companies mostly adopt cooperative forms to jointly advance. It
is recommended to focus on Fosun Pharma, which has reached a strategic
cooperation with BioNTech. Kangtai Biological, Zhifei Biological, etc.
Advise DPP authorities and Su Zhenchang to stop spreading political virus immediately
Zhu Fenglian, a spokesman for the State Council Taiwan
Affairs Office, said on the 24th that Su Zhenchang once again shamelessly
spread "Su-style lies", blatantly rumors that the mainland
"concealed the epidemic." This act of inciting discrimination and
hatred by making lies, once again exposed his vicious nature to the world.
Zhu Fenglian said that in the past two months or so, the
people of the mainland have united as one and worked hard to fight the
epidemic. The achievements they have achieved are universally recognized and
they have won precious time for epidemic prevention worldwide.
At the same
time, they have always taken a highly responsible attitude towards the lives and
health of the people of Taiwan. They have notified the relevant Taiwan
authorities of the epidemic from the beginning, including the information on
the mainland’s and WHO ’s sharing of the New Coronavirus gene sequence and
access to related gene sequence information.
As of March end, it has notified
101 times. The DPP authorities have never dared to tell these truths to the
people of Taiwan.
Zhu Fenglian pointed out that "Su-style lies" have
been repeatedly face-scrapped by facts. The epidemic situation in Taiwan is
intensifying. The DPP authorities and Su Zhenchang are advised to immediately
stop spreading the political virus. It is both shameful and disgusting to
continue to “ignite” the epidemic to raise cross-strait confrontation and
worsen the atmosphere of cross-strait relations.
New research finds that Pleurotus ostreatus has antiviral and anti-inflammatory effects on new crown virus
For the latest news, the scientific research team of
Academician Zhong Nanshan entitled "Lianhuaqingwen exerts anti-viral and
anti-inflammatory activity against novel coronavirus (SARS-CoV-2)" has
been accepted by the journal Pharmacological Research.
The authors of the paper include Zhong Nanshan, director of
the State Key Laboratory of Respiratory Diseases, Guangzhou Medical University,
and researcher Yang Zifeng.
"Pharmacological Research" is a well-known
pharmacological journal under the Elsevier Publishing Collective and a classic
pharmacological journal. This journal mainly publishes cutting-edge articles in
the field of biomedical science and enjoys a high reputation in the
pharmaceutical industry.
The paper mentions that as a traditional Chinese medicine
prescription, Lianhua Qingwen has broad-spectrum antiviral and immunoregulatory
effects on a range of influenza viruses.
The study found that Pleurotus ostreatus can significantly
inhibit the replication of Neocoronavirus in cells, and the expression of virus
particles in the cells was significantly reduced after treatment of Pediatricus
Plasmodium. IL-6, MCP-1 and IP-10 genes are over-expressed in a dose-dependent
manner.
This study confirms that even flower clear blast can play an
anti-neovirus activity by inhibiting virus replication, causing changes in the
shape of virus particles and suppressing the expression of inflammatory factors
in host cells. This shows that even flower clear blast can resist virus attack
and is expected to become a new crown for prevention New strategies for
pneumonia.
It is understood that Lianhua Qingwen is a prescription
formulated under the guidance of the theory of collateral disease and the
method of "clearing and detoxifying, demonstrating lungs and reducing
fever", and is recommended for colds, flu, and avian flu by 20 national
guidelines, consensus, and treatment plans. , Middle East Respiratory Syndrome
(MERS) and other respiratory diseases. At present, Lianhua Qingwen Capsule (granule)
has been included in the national version of "Pneumonitis Diagnosis and
Treatment Program for New Coronavirus Infection".
Traditional Chinese medicine for new coronary pneumonia, the total effective rate is more than 90%
At 16:00 on March 23, the State Council Information Office
held a press conference in Wuhan, Hubei to introduce the important role of
Chinese medicine in the prevention and treatment of new crown pneumonia and
effective drugs.
Yu Yanhong, member of the Central Steering Group, member of
the Party Committee of the Health and Health Committee, and secretary of the
Party Group of the Chinese Medicine Bureau, introduced that the State
Administration of Traditional Chinese Medicine has conducted simultaneous
observation of the clinical efficacy of proprietary Chinese medicines and
prescriptions that have been included in the fifth, sixth, and seventh edition
of the treatment plan "Jinhua Qinggan Granules, Lianhua Qingwen Capsules,
Xuebijing Injection and Qingfei Paidu Decoction, Huashi Baidu Decoction,
Xuanfei Baidu Decoction, etc." have been selected.
According to statistics, 74,187 of the confirmed cases
nationwide were treated with Chinese medicine, accounting for 91.5% of the
total; 61,449 patients in Hubei were treated with Chinese medicine, accounting
for 90.6%.
The clinical efficacy observations show that the total effective
rate of traditional Chinese medicine treatment is more than 90%, which
effectively relieves the symptoms of patients, reduces the development of light
and ordinary patients to heavy, improves the cure rate, reduces the mortality
rate, and promotes the physical recovery of the recovery period.
Yu Yanhong said that in the absence of specific medicines and
vaccines in the early stage of the new crown pneumonia epidemic, the law and
experience of traditional Chinese medicine in treating viral infectious
diseases were summarized, and ancient classics were deeply explored. Combined
with clinical practice, traditional Chinese medicine and traditional Chinese
and western medicine were formed.
Combined with the diagnosis and treatment
plan for the treatment of new coronary pneumonia, it has become an important feature
and advantage of the Chinese plan, and a batch of effective prescriptions
represented by "three drugs and three parties" were screened.
This
practice has fully proved once again that the precious wealth left by the old
ancestors of traditional Chinese medicine has been tried and tested for a long
time, and it is worth cherishing. It is still easy to use, effective, and
economically feasible.
In the epidemic, a large number of Chinese medicines were
approved
In the epidemic, a large number of Chinese medicines were approved
According to China Net News, on March 18, Huashi Baidu
Granule was approved by the State Drug Administration for clinical trials,
which is also the first Chinese medicine clinical approval for the treatment of
new coronary pneumonia in China.
Huashi Baidu Granules were developed by the first batch of
National Aid-resistant Anti-epidemic Traditional Chinese Medical Team (China
Academy of Chinese Medical Sciences) led by Huang Luqi, a member of the Chinese
Academy of Engineering and the president of the Chinese Academy of Chinese
Medical Sciences.
Huashi Badu Fang is the first batch of national medical teams
in the country to gradually form the process of "salvation while summing
up" during the actual treatment of Jinyintan Hospital and the Dongfanghu
Fangcai Hospital. It can fight the virus, eliminate inflammation, improve
immunity, and played an active role in the treatment of Wuhan New Crown
patients.
Academician Zhong Nanshan also previously stated at the
outbreak prevention and control conference held in Guangdong: "I attach
great importance to the role of traditional Chinese medicine in the laboratory
on the new crown virus. Once there is evidence, traditional Chinese medicine
can be used with confidence, especially in the early and middle stages."
On the one hand, the state recommends the use of effective
prescriptions for new coronary pneumonia traditional Chinese medicine; on the
other hand, a batch of traditional Chinese medicine preparations for new
coronary pneumonia have also been approved through emergency review.
According to Minnet.com, as of the end of February, 21
Chinese medicine preparations have been approved by the provincial drug
regulatory bureaus to prevent and control pneumonia outbreaks of new
coronavirus infections.
As Academician Zhang Boli said at the State Council press conference
on March 23, "I don't panic if you have medicine in your hand. Every time
after a major epidemic, a good medicine will come out, so there is a
saying," The epidemic "Good medicine," after a major epidemic, a
batch of good medicine will be issued. "
In response to the new crown pneumonia epidemic, we have no
specific medicines or vaccines, but in the process of epidemic prevention, we
can actively explore the path of integrating traditional Chinese and western
medicine for different patients, which is another improvement of traditional
Chinese medicine.
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videos are also included) are uploaded and published from users of the media
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storage services.
Tracing the virus all night long: The quality of the epidemiological investigation is related to whether the source of infection and potential infected persons can be identified in time, and the spread of the epidemic can be controlled.
Yuan Jun,
chief physician of the Guangzhou Municipal Center for Disease Control and
Prevention, as the team leader of the emergency treatment team for the
prevention and control of new crown pneumonia in the city, led the team members
of the "detective" for disease control to break the cocoons and solve
the "mysteries" of virus transmission.
Aid Xinjiang returns to the front line in half a month
In early January, Yuan Jun ended three years of aid to
Xinjiang and returned to Guangzhou for a rest. As the situation of prevention
and control of the new crown pneumonia epidemic in Guangzhou gradually became
tense, he twice asked the unit for approval after the war and officially
returned to work.
On the third day of this year, Yuan Jun was appointed as the
leader of the emergency treatment team for the new crown pneumonia prevention
and control of the Municipal Center for Disease Control and Prevention.
Yuan Jun said that he studied preventive medicine at the
university. SARS, H1N1 influenza, H7N9 bird flu and other major public health
incidents were on the front line. In 2005, he went to Beijing to participate in
the two-year China Field Control Epidemiology Training Program of the Chinese
Centers for Disease Control and Prevention (Fifth Phase).
Most of the 12
graduates in the current period were in the frontline during this war.
"This epidemic is the time when our values are best reflected, and also
when the country and the people need them most. As a public health doctor and a
party member, I must rush to the front line, otherwise, my life will Sorry.
"
The epidemiological investigation is one of the core tasks of
the CDC in the prevention and control of infectious diseases, and it is also
the main work of the emergency treatment team of the Municipal Center for
Disease Control and Prevention led by Jun Jun.
Where does the virus come from? Who else might it spread to?
"Only by identifying the source of infection and close contacts of the cases and isolating them in time, can the immune system be prevented from spreading further.
Tracing the source of infection with a team of 200 people
In order to reshape the chain of transmission, Yuan Jun and
his colleagues went to the patient's home, to the hospital, to the various
places that the patient had visited 14 days before the onset of the disease, to
find the patient, to see the doctor, to find everything that could be found in
these 14 days. People who have been in contact, observe whether the on-site
environment is likely to cause conditions for transmission, and understand
their whereabouts.
The quality of the epidemiological investigation determines
whether the prevention and control work is accurate and whether the source of
infection and the route of transmission can be "early grasped". Since
the outbreak of the "epidemic", Yuan Jun, as the leader of the
emergency response team, has established a joint urban epidemiological
investigation team of more than 200 people.
The quality of the epidemiological
investigation report has thus been greatly improved in a short period of time.
The ratio of each case to the close contacts found has increased from 1: 2 in
January to the current 1:13, ensuring the prevention and control effect.
Although the scope of this work was in Guangzhou, Yuan Jun
was almost absent from home every day: In order to gather time for the clues of
epidemiological investigations, he and his colleagues often dispatched field
investigations throughout the night. Without entering. " Even if I go home
occasionally at night, it’s mostly late at night. I’m going to change clothes
and my family is asleep. Occasionally, I go home early because I’m worried
about the risks of going out of the hospital and other places. Able to avoid
it.
"The new crown virus is more cunning than the SARS
virus, because the infected person may not have a fever or asymptoms, which
adds a lot of difficulty to us in terms of prevention and control.
However,
even if it is difficult, we must try our best to do it as soon as possible.
Keep it under control, suppress the epidemic situation, delay the spread of the
process, and find time for effective research and development of vaccines for
clinical research and development, "said Jun Jun."
As long as the
epidemic can be controlled as early as possible, all the suffering is worth it.
"
According to the authoritative statement issued by the
Jiangsu Provincial Health and Health Commission on March 20: at 04:00 on March
last day, there were no new confirmed cases of new coronavirus pneumonia in
Jiangsu.
- 93 cases in Nanjing
- 55 cases in Wuxi
- 79 cases in Xuzhou
- 51 cases in Changzhou
- 87 cases in Suzhou
- 40 cases in Nantong
- 48 cases in Lianyungang
- 66 cases in Huai'an
- 27 cases in Yancheng
- 23 in Yangzhou
There were:
- 12 cases in Zhenjiang
- 37 cases in Taizhou
- 13 cases in Suqian
A total of 631
discharged patients.
At present, Jiangsu Province has tracked 12,657 close
contacts, 12,644 people have been released from medical observation, and 13
people are still receiving medical observation.
Experts remind: Although the cases confirmed in the hospital
are "cleared", it does not mean "zero risk". At present,
the situation of overseas epidemics is very serious. We must be cautious and
prevent importation.
We must not relax our vigilance against epidemics and
reduce the requirements for prevention and control. We must ensure that work is
not slack and epidemics do not rebound.
The public must continue to be aware of precautions and
develop good hygiene habits, such as wearing a mask, washing hands frequently,
paying attention to cough etiquette, and ventilating and cleaning the room
daily to minimize aggregation and effectively reduce the risk of infection.
Appointment consultations have been implemented in hospitals
above the provincial level. In order to reduce the staff gathering and shorten
the waiting time in the hospital, please register in advance through a variety
of channels, such as online registration, mobile APP appointments, phone
appointments, SMS appointments, clinic appointments, on-site self-service
appointment appointments, etc.
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