Ad Banner

Respiratory Syncytial Virus Infection Cause Effect


How does respiratory syncytial virus infection cause?

Caused by respiratory syncytial virus or fusion virus (RSV). It belongs to paramyxovirus RNA type, with a diameter of 100-140nm. The nucleocapsid is composed of 32 symmetrical icosahedral capsids and has a capsule. Not destroyed by ether and chloroform. Human cells, diploid cells, and primary monkey kidney cells can be used to culture viruses and produce special fusion cells. With fluorescent antibody technology, the virus can be detected in the cytoplasm of infected cells. The disease is transmitted through the droplet respiratory tract and has the characteristics of wide spread, high infection rate, and long duration. It is spread and spread in various countries around the world, and a major epidemic occurs almost every year or every other year.
Diagram of respiratory syncytial virus infection

 Pathogenesis of Respiratory syncytial virus infection

Respiratory syncytial virus infection passes through air droplets or directly into the respiratory tract of susceptible persons. After RSV invades the body, it first multiplies in the nasopharyngeal mucosa and causes upper respiratory tract infection.

Infants with low immune function, the elderly, RSV can extend from the nasopharynx to bronchial and alveolar levels at all levels, and then develop severe bronchitis, bronchiolitis and pneumonia.

Respiratory virus invades human ciliary epithelial cells on the surface of the respiratory tract, replicates and spreads within it and directly causes damage to infected cells, causing local lesions or producing symptoms of systemic toxins.

Some virus-infected tissue damage may be mediated by the body's immune response. For example, respiratory syncytial virus has the least direct damage to respiratory cilium epithelial cells, but can cause serious respiratory diseases in infants and young children; the most vulnerable age is mother-to-child transmission. 

The stage of the highest antibody level

Aafter the vaccination, the condition of the naturally infected person is worsened, all suggesting that the onset may be related to the immune response. The pathological changes of respiratory virus infection include nasal, pharyngeal, and laryngeal mucosal congestion, edema, exudation, and monocyte infiltration. Some cells can degenerate, necrotize, and fall off. Inclusion bodies can be seen in the cytoplasm or nucleus of epithelial cells. 
Diagnosis of respiratory syncytial virus infection cause
The extent of the disease is related to the type, type and site of infection. After a few days, the epithelial cells can regenerate and return to normal. If the lesion involves the bronchioles, epithelial cell necrosis and exfoliation can occur. The bronchiolar wall has extensive mononuclear cell infiltration. Fibrin, cell debris and thick mucus can block the lumen and cause atelectasis and emphysema. 

Viral Pneumonia Manifestation

Viral pneumonia initially manifests as a progressive reduction of cilia, formation of vacuoles in epithelial cells, followed by degeneration of epithelial cells, substantial necrosis and collapse of alveoli, necrosis and thickening of alveolar walls, interstitial edema and monocytes, lymphocytes infiltration.
When bacterial infection is complicated, mucosal hyperemia, neutrophil infiltration, and mucopurulent secretion can be seen. In severe cases, pulmonary abscess, sepsis and purulent changes in multiple organs can occur.


Post a comment

0 Comments